Yea some pretty damned stupid stuff. I mean consider the danger of making any modifications without a full understanding, as I understand it, there are so many cross dependencies between genes that there is almost impossible to predict what side effects editing may cause before they appear, like the kindeys might stop working at some point.
Oh and also whatever change will be passed on and as the recipients reproduce.
Also it has been found that CRISPR isn't as precise and foolproof as originally widely reported. So even if you knew exactly what you were doing in terms of editing, your edits may not occur as intended.